Anti-Inflammatory Therapy with High Dose Insulin in Brain Dead Organ Donors

Assessment of Brain-Dead Potential Organ Donors

Introduction: We quantified the potential for organ donation and identified missed opportunities for organ donation in a single institute. Materials and methods: Data of potential organ donors and the outcome of requests fororgan donation in the intensive care unit (ICU) of Ajou University Hospital between January 2013 and July 2015 were collected and reviewed. Results: Of 1338 deaths that occu...

A review of studies relating to thyroid hormone therapy in brain-dead organ donors.

An acute decrease in cardiac performance can result from a reduced free triiodothyronine (FT3) level following (i) brain death (euthyroid sick syndrome), (ii) a period of cardiopulmonary bypass, and possibly (iii) regional or global myocardial ischemia. The two major pathophysiologic effects of brain death are (i) vascular injury associated with the hemodynamic consequences of the autonomic 'st...

University of Groningen Steroid Anti-Inflammatory Effects Did Not Improve Organ Quality in Brain-Dead Rats

Steroid Anti-Inflammatory Effects Did Not Improve Organ Quality in Brain-Dead Rats

Effect of glucocorticoid administration on improving the outcomes of kidney and liver allografts has not been clearly elucidated. This study investigated the effect of prednisolone administration after onset of brain death (BD) on kidney and liver in a controlled rat model of BD. BD was induced in rats by inflating an epidurally placed balloon catheter. Animals were treated with saline or predn...

Hormone resuscitation therapy for brain-dead donors - is insulin beneficial or detrimental?

Hormonal replacement therapy to brain-dead potential organ donors remains controversial. A retrospective study was carried out of hormonal therapy on procurement of organs in 63 593 donors in whom information on thyroid hormone therapy (triiodothyronine or levothyroxine [T3 /T4 ]) was available. In 40 124 donors, T3 /T4 and all other hormonal therapy were recorded. The percentage of all organs ...